Companies working at the frontier of physics, chemistry, and biology — where the moat is the science itself.
All
Energy & Climate
Biotech & AI
Health
Materials & Hardware
Space & Autonomy
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Aalo Atomics
Factory-built modular nuclear reactors designed to power AI data centers — targeting criticality in 2026 with the first advanced reactor built in the US in a generation.
Nuclear Energy
Austin
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ALT TEX
Sustainable textile materials from agricultural waste — replacing virgin synthetics and conventional cotton in mainstream apparel supply chains.
Sustainable Materials
Toronto
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Avro Life Science
A transdermal patch that delivers medications through the skin — making therapies more accessible by removing the need for injections or clinical administration.
Cell & Gene Therapy
Waterloo
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Bioform
Biomaterial platform developing novel biological scaffolds for applications in medicine, construction, and industrial design.
Biomaterials
Vancouver
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Eli Health
Hormone diagnostics from saliva — making continuous hormonal monitoring accessible outside a clinic, starting with fertility and expanding across the full hormonal health landscape.
Hormone Diagnostics
Montreal
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E-Zinc
Grid-scale zinc-air batteries that store energy for days rather than hours — a low-cost, earth-abundant answer to long-duration storage that lithium chemistries can't solve.
Long-Duration Storage
Toronto
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Faction
Teleoperated electric delivery vehicles with a remote human in the loop — making autonomous last-mile delivery commercially viable today, without waiting for full Level 5.
Autonomous Vehicles
San Francisco
Shut Down
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GaN Systems
Gallium nitride power semiconductors enabling smaller, faster, more efficient power electronics. Acquired by Infineon Technologies in 2023 — validating GaN as the successor to silicon in power conversion.
Power Semiconductors
Ottawa
Acquired by Infineon Technologies
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Jetson Home
Consumer heat pump systems designed to make home electrification accessible — removing the friction that keeps households tethered to fossil fuel heating.
Home Electrification
Vancouver
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Kalino Bio
Non-surgical immunocontraceptives for animals — a biological alternative to surgical sterilization with implications for wildlife management and companion animal care.
Biotech
Vancouver
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Membio
Single-use bioreactor technology for cell therapy and bioprocessing manufacturing — acquired by ABEC, a global leader in biopharmaceutical process equipment.
Bioprocessing
Toronto
Acquired by ABEC
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LightCell Energy
Next-generation electrochemical energy storage targeting lower cost and longer cycle life than existing chemistries for grid and industrial applications.
Energy Storage
San Francisco
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Mast Reforestation
Carbon sequestration through biomass burial — harvesting excess plant matter and storing it underground where it can't decompose and release CO₂ back into the atmosphere.
Reforestation
Seattle
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Nanode
A novel battery anode using a proprietary nanomaterial process — delivering higher energy density and longer cycle life for electric vehicles and grid storage.
Nanotechnology
Edmonton
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Phenomic AI
AI-powered cell morphology platform identifying novel drug targets in solid tumour stroma — addressing cancers where current therapies routinely fail.
AI Drug Discovery
Toronto
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Planetary
Ocean alkalinity enhancement that permanently removes CO2 at scale. XPRIZE Carbon Removal winner. $31M Frontier offtake with Stripe, Shopify, and others.
Carbon Removal
Dartmouth
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Raven Telemetry
AI-powered manufacturing intelligence platform providing real-time visibility into factory floor operations — turning sensor data into actionable production insights.
Manufacturing AI
Ottawa
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ProteinQure
Computational protein design using machine learning to develop peptide therapeutics faster and more precisely than traditional biochemical methods.
Protein Design
Toronto
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QurCan
Nanoparticle RNA delivery targeting the brain and spleen — tissue destinations that have historically been out of reach for RNA therapeutics.
RNA Delivery
Toronto
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SpaceRyde
Balloon-launched rocket system designed to deliver small satellites to orbit at a fraction of traditional launch costs — a genuinely novel approach to the last-mile access problem.
Space Launch
Toronto
Shut Down
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Synova Life Sciences
Regenerative medicine developing biologically-active tissue repair solutions for musculoskeletal and soft tissue injuries.
Regenerative Medicine
Pasadena
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Valence Labs
AI platform for molecular discovery — acquired by Recursion Pharmaceuticals in 2023, becoming part of one of the world's leading computational drug discovery companies.
AI Drug Discovery
Montreal
Acquired by Recursion Pharmaceuticals
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Varda Space
Orbital manufacturing using microgravity to produce materials impossible to make on Earth. Four successful missions to date. $329M raised. Pharmaceuticals crystallized in space and returned by re-entry capsule.
Space Manufacturing
El Segundo
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Vessl Prosthetics
Self-adjusting prosthetic sockets that automatically adapt to daily volume changes in the residual limb — solving the most common cause of prosthetic abandonment.
Medical Devices
London
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Vital Bioscience
Point-of-care diagnostic platform (VitalOne) running lab-quality tests at the bedside in minutes — compressing hours of lab turnaround to the moment of care.
Point-of-Care Diagnostics
Toronto
Occasionally we back exceptional founders building outside deep tech — people we know personally, solving problems that have a huge impact.
We invest at the angel or pre-seed stage — long before institutional capital arrives. The companies we back have gone on to raise from some of the most respected names in venture.
Andreessen Horowitz
Founders Fund
Khosla Ventures
Y Combinator
Tiger Global
Lux Capital
Bessemer Venture Partners
Accel
Spark Capital
IVP
Valor Equity Partners
Felicis Ventures
First Round Capital
FirstMark Capital
Craft Ventures
True Ventures
Caffeinated Capital
Kindred Ventures
We back world-class fund managers with deep sector expertise or access to founders we wouldn't reach on our own. If you're raising a fund in this space, we'd like to hear from you.
